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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1918 1
1930 1
1946 1
1947 1
1949 2
1950 3
1951 3
1952 3
1953 1
1954 7
1955 12
1956 11
1957 11
1958 14
1959 22
1960 22
1961 33
1962 29
1963 63
1964 117
1965 97
1966 116
1967 205
1968 203
1969 217
1970 194
1971 253
1972 227
1973 227
1974 267
1975 406
1976 371
1977 409
1978 493
1979 618
1980 688
1981 736
1982 789
1983 772
1984 800
1985 774
1986 758
1987 802
1988 860
1989 1052
1990 1048
1991 1163
1992 1251
1993 1317
1994 1382
1995 1378
1996 1372
1997 1515
1998 1577
1999 1638
2000 1955
2001 1955
2002 2207
2003 2171
2004 2267
2005 2555
2006 2842
2007 3040
2008 3246
2009 3447
2010 3992
2011 4069
2012 4429
2013 4851
2014 5571
2015 5903
2016 6352
2017 6650
2018 6988
2019 7597
2020 8987
2021 9431
2022 8822
2023 9024
2024 4230

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135,899 results

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Page 1
Mitochondrial dysfunction in cell senescence and aging.
Miwa S, Kashyap S, Chini E, von Zglinicki T. Miwa S, et al. J Clin Invest. 2022 Jul 1;132(13):e158447. doi: 10.1172/JCI158447. J Clin Invest. 2022. PMID: 35775483 Free PMC article. Review.
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. ...Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major consequences of mitochondrial …
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. ...Here, we summar …
Hallmarks of T cell aging.
Mittelbrunn M, Kroemer G. Mittelbrunn M, et al. Nat Immunol. 2021 Jun;22(6):687-698. doi: 10.1038/s41590-021-00927-z. Epub 2021 May 13. Nat Immunol. 2021. PMID: 33986548 Review.
This decline is responsible for elevated susceptibility to infection and cancer, as well as decreased vaccination efficacy. Recent evidence indicates that CD4(+) T cell-intrinsic alteratins contribute to chronic inflammation and are sufficient to accelerate an organism-wid …
This decline is responsible for elevated susceptibility to infection and cancer, as well as decreased vaccination efficacy. Recent evidence …
Stem cell aging.
Rudolph KL. Rudolph KL. Mech Ageing Dev. 2021 Jan;193:111394. doi: 10.1016/j.mad.2020.111394. Epub 2020 Nov 9. Mech Ageing Dev. 2021. PMID: 33181161 No abstract available.
Single-cell analyses of aging, inflammation and senescence.
Uyar B, Palmer D, Kowald A, Murua Escobar H, Barrantes I, Möller S, Akalin A, Fuellen G. Uyar B, et al. Ageing Res Rev. 2020 Dec;64:101156. doi: 10.1016/j.arr.2020.101156. Epub 2020 Sep 16. Ageing Res Rev. 2020. PMID: 32949770 Free PMC article. Review.
This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie aging, including chronic inflammation (inflammaging), immunosenescence and cellular senescence. ...For example, in some data …
This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie ag
A stem cell aging framework, from mechanisms to interventions.
Liu B, Qu J, Zhang W, Izpisua Belmonte JC, Liu GH. Liu B, et al. Cell Rep. 2022 Oct 18;41(3):111451. doi: 10.1016/j.celrep.2022.111451. Cell Rep. 2022. PMID: 36261013 Free article. Review.
Decades of scientific research have uncovered processes of stem cell decline in tissue and organismal aging, and more recently, pioneering technologies permit the dissection of its underlying mechanisms and inform therapeutic development for aging and agin
Decades of scientific research have uncovered processes of stem cell decline in tissue and organismal aging, and more recently …
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo.
Ogrodnik M. Ogrodnik M. Aging Cell. 2021 Apr;20(4):e13338. doi: 10.1111/acel.13338. Epub 2021 Mar 12. Aging Cell. 2021. PMID: 33711211 Free PMC article. Review.
These markers are now used to measure the impact of cellular senescence on aging and disease as well as outcomes of anti-senescence interventions, many of which are at the stage of clinical trials. ...Specifically, this review article seeks to describe …
These markers are now used to measure the impact of cellular senescence on aging and disease as well as outcomes of ant …
Human PBMC scRNA-seq-based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity.
Zhu H, Chen J, Liu K, Gao L, Wu H, Ma L, Zhou J, Liu Z, Han JJ. Zhu H, et al. Sci Adv. 2023 Jun 28;9(26):eabq7599. doi: 10.1126/sciadv.abq7599. Epub 2023 Jun 28. Sci Adv. 2023. PMID: 37379396 Free PMC article.
Here, we generate a reference 28-sample aging cohort to compute a single-cell level aging clock and to determine the biological age of SCs. ...Inhibiting ribosomal activity or translation in monocytes validates such translation against inflammation balance re …
Here, we generate a reference 28-sample aging cohort to compute a single-cell level aging clock and to determine the bi …
Regulation of Stem Cell Aging by Metabolism and Epigenetics.
Ren R, Ocampo A, Liu GH, Izpisua Belmonte JC. Ren R, et al. Cell Metab. 2017 Sep 5;26(3):460-474. doi: 10.1016/j.cmet.2017.07.019. Epub 2017 Aug 17. Cell Metab. 2017. PMID: 28826795 Free article. Review.
Stem cell aging and exhaustion are considered important drivers of organismal aging. ...Recent studies have shown that metabolism plays an important role in regulating epigenetic modifications and that this regulation dramatically affects the aging pro …
Stem cell aging and exhaustion are considered important drivers of organismal aging. ...Recent studies have shown that …
T cell aging and Alzheimer's disease.
Guo L, Li X, Gould T, Wang ZY, Cao W. Guo L, et al. Front Immunol. 2023 Apr 4;14:1154699. doi: 10.3389/fimmu.2023.1154699. eCollection 2023. Front Immunol. 2023. PMID: 37081887 Free PMC article. Review.
Age is the primary risk factor for Alzheimer's disease (AD), resulting in marked age-dependent changes in T cells. Manipulating peripheral T cell immune response has been shown to impact AD, but the relationship between T cell aging and AD remains poorly unde …
Age is the primary risk factor for Alzheimer's disease (AD), resulting in marked age-dependent changes in T cells. Manipulating peripheral T …
135,899 results
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